Calpain Inhibitor II, powder

Application

Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Calpain Inhibitor II has been used in western blotting. It has also been used to study the mechanism of Spy1A (a cyclin-like protein) degradation during cell cycle.

Biochem/physiol Actions

Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.

Other Notes

Formerly CAS# 136632-32-1

Packaging

5, 25 mg in glass bottle